Registration Dossier
Registration Dossier
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EC number: 249-978-2 | CAS number: 29964-84-9
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study planned
- Justification for type of information:
- CONSIDERATIONS OF ALTERNATIVE METHODS ON TESTING PROPOSALS IN YOUR REGISTRATION
Public substance name: Isodecyl methacrylate or IDMA
EC Number: 249-978-2
CAS Number: 29964-84-9
• Hazard endpoint for which vertebrate testing was proposed:
Fish early-life stage toxicity study with Isodecyl methacrylate or IDMA (EC 249-978-2 ) according to the OECD Test Guideline 210.
• available GLP studies
None
• available non-GLP studies
None
• historical human data
Not relevant
• (Q)SAR
To our knowledge, there is no appropriate QSAR for estimating chronic toxicity with same endpoints as the OECD TG 210.
• in vitro methods
To our knowledge, there is no validated in vitro test method for estimating chronic toxicity with same endpoints as the OECD TG 210.
• weight of evidence
There are not enough available data for a weight of evidence approach. No acute toxicity data for daphnia are available to compare sensitivity between the three trophic levels. Additionally, the acute toxicity study conducted with fish is limited as well as it only investigated the effects of a static saturated solution.
• grouping and read-across
There are no identified groups of substances or similar substances for a read across approach.
• Considerations that the specific adaptation possibilities of Annexes VI to X (and column 2 thereof) were not applicable:
No long-term toxicity to fish study is available for the registered substance.
The REACh Annex IX, Section 9.1., Column 2 does not allow omitting the need to submit information on long-term toxicity to fish under Column 1. Therefore, fish long-term toxicity testing is a standard information requirement under annex IX of REACh regulation EC 1907/2006. Therefore, an OECD 210 study is proposed and cannot be waived.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Isodecyl methacrylate
- EC Number:
- 249-978-2
- EC Name:
- Isodecyl methacrylate
- Cas Number:
- 29964-84-9
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 2-methylnonyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
