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Diss Factsheets
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EC number: 203-820-9 | CAS number: 110-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: Dermal irritation tests with humans revealed some dermal irritation potential for DIPA.
Skin sensitisation: 2% DlPA (aqueous solution) did not induce allergic or photoallergic dermatitis. Case reports with formulations containing DIPA are available, two human patch tests were performed including control subjects.
Additional information
Skin Irritation (IUCLID section 7.10.5):
In a human patch test (Cronin, 1980) 24 volunteers received undiluted DIPA to the skin and dermal irritation was observed in six individuals.
Skin Sensitisation (IUCLID section 7.10.3):
DlPA (2% aqueous solution) did not induce allergic or photoallergic dermatitis (Maibach, 1986; cited in J.Am.Coll.Toxicol., 1987: 6(1), 53 -76).
In a case report (Cronin, 1980; RL2), a 15 years old girl complained of irritation of her eyelids and face for six months and attributed this to her cosmetics. When patch tested, she reacted only to her eye gloss; she was then tested to its ingredients, and reacted to diisopropanolamine, undiluted. This substance also gave a positive open test; as it is an irritant, it should have been diluted for patch testing. It was, in fact, tested undiluted on 24 control subjects of whom six gave irritant responses. Nevertheless, the patient's reaction did not look irritant, it was eczematous and spread beyond the patch test site; for this reason it was considered an allergic response.
In another case report (Fujimoto, 1989; RL4) a 60-year-old man with gout used indomethacin ointmnet containing 1% diisopropanolamine. A diffuse and edematous erythema, accompanied by a febrile sensation and severe itching was present. A patch-test with 1% diisopropanolamine in vaseline gave positive reaction. Of 12 control subjects patch tested with DIPA I% pet., 11 were negtive and 1 gave a false positive reaction.
Several studies with sunscreen lotion containing 1 -2% DIPA are available (cited in J.Am.Coll.Toxicol., 1987: 6(1), 53 -76), however, details about test material (e.g. other ingredients than DIPA) are not available. Thus, these data are not included to the dossier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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