Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-114-8 | CAS number: 1303-00-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
There exist the following mutagenicity studies with full reliability:
- in-vitro gene mutation in bacteria (Zeiger et al. 1992),
- in-vitro gene mutation in mammalian cells (Stone, 2010) and the
- in-vivo micronucleus test (NTP, 2000).
The in-vitro micronucleus test (Gibson et al. 1997) has also a sufficient but no full reliability.
Not sufficiently reliable are the sudies of Kerckaert et al. (1996), cell transformation test in SHE cells, and of Duerksen-Hughes et al. (1999), p53 induction in vitro. They used no standard study protocol and the specificity and selectivity of their test system has not been proven sufficiently reliable, therefore these 2 studies are ignored.
Husgavfel-Pursiainen et al. (1990) published results from a sister-chromatid exchange study and a chromosome aberration study in GaAs exposed CHO cells. Both studies showed negative results. However, these studies were considered as not assignable and could not be evaluated for their reliability due to availability as abstracts only.
The studies with sufficient reliability are negative and clearly show that GaAs is not mutagenic or genotoxic.
Short description of key information:
The following mutagenicity studies with sufficient reliability are available: in-vitro gene mutation in bacteria (Zeiger et al. 1992), in-vitro micronucleus test (Gibson et al. 1997), in-vitro gene mutation in mammalian cells (Stone, 2010) and in-vivo micronucleus test (NTP, 2000).
All study results are negative for the respective endpoints. In conclusion, the results of these studies clearly show that GaAs is not mutagenic or genotoxic. A classification with regard to genotoxicity is not required.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Results of the studies with sufficient reliability are negative and clearly show that GaAs has no genotoxic or mutagenic effects.
Therefore a classification according to CLP regulation and subsequent regulations with regard to mutagenicity or genotoxicity is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
