Hexane, 1,6-diisocyanato-, homopolymer, 3,5-dimethyl-1H-pyrazole-blocked

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

< 0.1 mg/L

Temp.:

20 °C

pH:

6

Details on results:

The test item is determined to be insoluble in demineralized water within the test duration and remains as an undissolved solid residue.

Calibration Curve of standard solutions (concentration range 0.054 – 1.08 mg/L test substance)

The limit of quantification (LOQ) of the analytical method was set to 0.1 mg/L. For this concentration a high signal to noise ratio > 10 was obtained. The analytical method ensures a specific and sensitive determination of the test item.

Aqueous test solutions after filtration

Water solubility at 20 °C	Flask A [mg/L]	Flask B [mg/L]	Flask C [mg/L]	Mean value
Concentration test item [mg/L]	< 0.1	< 0.1	< 0.1	--*
pH-value	6.05	6.02	6.01	6.0

* not calculated because all values are < 0.1 mg/L

Conclusions:

Interpretation of results: insoluble (< 0.1 mg/L)
The water solubility of the substance in demineralized water was determined with the flask method at 20 °C according to OECD TG 105. The test item is determined to be insoluble in demineralized water within the test duration and remains as an undissolved solid residue. Water solubility at 20 °C and pH6 is: < 0.1 mg/L.

Executive summary:

The water solubility of the test substance in demineralized water was determined with the flask method at 20 °C according to OECD TG 105.

Based on a preliminary test the concentration of the dissolved amount of the test item in the aqueous test solutions was determined in a first step by total organic carbon (TOC).

In addition, the concentration of the main component of the test item in the aqueous test solutions was determined specifically by HPLC-MS-analysis reaching a lower limit of quantification. The test item is determined to be insoluble in demineralized water within the test duration and remains as an undissolved solid residue. Water solubility at 20 °C and pH6 : < 0.1 mg/L.

Description of key information

The water solubility of the substance in demineralized water was determined

with the flask method at 20 °C according to OECD TG 105. The test item is determined to be insoluble in demineralized water within the test duration and remains as an undissolved solid residue. Water solubility at 20 °C and pH6 is: < 0.1 mg/L

Key value for chemical safety assessment

Water solubility:

0.1 mg/L

at the temperature of:

20 °C

Additional information

"should read < 0.1 mg/L"