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EC number: 242-056-0
CAS number: 18171-19-2
Table 1. Test results
Table 2. Results of analysis of test media
Concentration used as the basis for assessing effects (mg/L)
72 hour ErC50 437
mg/l ErC10 137 mg/l and NOEC 57 mg/l (nominal concentration)
(EU Method C.3 (Algal Inhibition test)), read-across from an
analogous/structurally related substance,
3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3). The observations
in this study are attributed to the exposure of test organisms to the
hydrolysis products in the test system. The result may be expressed in
terms of concentration of the hydrolysis product: 72 hour ErC50 321
mg/l and ErC10 101 mg/l as 3-chloropropyl(methyl)silanediol.
No data are available for toxicity
of the registration substance, 3-chloropropyl(dimethoxy)methylsilane
(CAS 18171-19-2), to algae. However, data are available from the related
substance 3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3). Both
substances have the same silanol hydrolysis product,
3-chloropropyl(methyl)silanediol. The other hydrolysis products are
methanol and ethanol, respectively. In the test with
3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3), the observations
are attributed to the exposure of test organisms to
3-chloropropyl(methyl)silanediol in the test system. There is no basis
to expect that ethanol significantly influenced the results of the
tests. The toxicity of ethanol is discussed further in the RAAF report
for ecotoxicity attached in Annex 4 of the CSR and Section 13 of IUCLID.
A 72 hour ErC50 value
of 437 mg/l, ErC10 value of 137 mg/l and
NOEC value of approximately 57 mg/l have been determined for the
effects of 3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3) on
growth rate of Desmodesmus subspicatus. The results have
been reported in terms of nominal concentrations of parent substance.
Due to the hydrolysis rate of the test substance (9.5 hours at pH 7) and
test media preparation methods (stirring for 18 hours prior to addition
of test organisms), it is very likely that the test organisms were
exposed to the hydrolysis products 3-chloropropyl(methyl)silanediol and
ethanol. The results may be expressed in terms of concentration of the
hydrolysis product, 3-chloropropyl(methyl)silanediol, by applying a
molecular weight correction: (MW of silanol = 154.67 / MW of parent =
210.78) * [CONCENTRATION OF PARENT = EC50 437 mg/l and EC10 137
mg/l] = ErC50 321 mg/l and ErC10 101 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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