Registration Dossier
Registration Dossier
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EC number: 202-426-4 | CAS number: 95-51-2
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented publication which meets basic scientific principles, but no guideline followed
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute renal and hepatic toxicity of 2-haloanilines in Fischer 344 rats
- Author:
- Valentovic, MA et al.
- Year:
- 1 992
- Bibliographic source:
- Toxicology, 75: 121-131
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- After i.p. injection of 1.0 or 1.25 mmoles/kg in male Fischer 344 rats (>= 4 per group),urin output, reduced kidney weight, tubular casts and accumulation of p-aminohippurate and tetraethylammonium by renal cortical slices obtained from treated animals was determined 24 hours p.a..
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- 2-chloroaniline
- EC Number:
- 202-426-4
- EC Name:
- 2-chloroaniline
- Cas Number:
- 95-51-2
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 2-chloroaniline
- Details on test material:
- - Name of test material (as cited in study report): 2-chloroaniline hydrochloride
- Analytical purity: highest purity available, no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male
Administration / exposure
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- see remarks on results
- Frequency of treatment:
- see remarks on results
- Post exposure period:
- see remarks on results
Doses / concentrations
- Remarks:
- Doses / Concentrations:
see remarks on results
Basis:
- No. of animals per sex per dose:
- see remarks on results
- Control animals:
- other: see remarks on results
Results and discussion
- Details on results:
- see remarks on results
Any other information on results incl. tables
After i.p. injection of 1.0 or 1.25 mmoles/kg in male
Fischer 344 rats (>= 4 per group), reduced urin output,
reduced kidney weight, tubular casts and a reduced
accumulation of p-aminohippurate and tetraethylammonium by
renal cortical slices obtained from treated animals was
observed 24 hours p.a.. Blood urea nitrogen levels were
increased significantly at both concentrations.
Morphological changes in the kidneys were minor. Hepatic
alterations were characterised by elevated plasma ALT/GTP
levels and morphological changes in the centrilobular
region.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
