Registration Dossier
Registration Dossier
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EC number: 203-402-6 | CAS number: 106-48-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- 1 male and 1 female rabbit were tested for local skin tolerance by application of a gauze patch filled with the test substance on the hairless skin of the ear
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-chlorophenol
- EC Number:
- 203-402-6
- EC Name:
- 4-chlorophenol
- Cas Number:
- 106-48-9
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 4-chlorophenol
- Details on test material:
- - Name of test material (as cited in study report): p-chlorophenol
- Analytical purity: not reported
- Lot/batch No.: 2287
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hacking and Churchill Ltd., Huntingdon, England
- Weight at study initiation: 3-4 kg
- Housing: individual in rabbit cages
- Diet: Kaninchenmischfutter Z 222, ad libitum
- Water: ad libitum
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: hairless
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g - Duration of treatment / exposure:
- 1 and 8 h
- Observation period:
- 7 days
- Number of animals:
- 1 male and 1 female
1 further animal not tested due to the corrosive response in the first animals - Details on study design:
- TEST SITE
- Area of exposure: 6.25 cm² on the hairless skin of the ear
- Type of wrap if used: The treated skin was covered with gauze patch, held in place with adhesive bandage
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: very strong erythema with partial skin corrosion
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 8h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: very strong erythema with partial skin corrosion
- Irritant / corrosive response data:
- After removal of the bandage the two treated animals (1 and 8 h exposed rabbits respectively) showed a very strong erythema with partial skin corrosion during the entire follow-up. Up to two days after treatment, the skin was also slightly swollen.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: Skin Corr. 1B, H314
DSD: C, R34
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