Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 421-820-9 | CAS number: 192268-65-8 CD 28-0132; IRGALUBE 232
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The substance is not acutely toxic to fish in the range of solubility.
Key value for chemical safety assessment
Additional information
Whole substance (CAS 192268 -65 -8)
A study conducted according to OECD guideline 203 with the uvcb substance is available (RCC Umweltchemie AG, 1997). A water accommodated fraction was prepared for the investigation. Zebra fish were used as test organisms and the LC50 after 96 hours of semi-static exposure was determined to be > saturation concentration (undiluted filtrate of a nominal loading rate of 100 mg/L). No effects were observed up to highest tested concentration and saturation concentration, respectively.
Structure A (CAS 597 -82 -0)
Two studies on the acute toxicity to fish are available.
In the most recent study (RCC 2002) which was performed according to GLP, zebra-fish (Brachydanio rerio) were exposed for 96-h to the test item at concentrations of 0 (control, solvent control) and saturation concentration (undiluted filtrate with a nominal loading rate of 100 mg/L) under static conditions. The 96-h LC50 was higher than the saturation concentration. The NOECs, based on mortality and sublethal effects, were ≥ the saturation concentration, respectively. Sublethal effects were not observed.
In addition, the 96-h acute toxicity to zebra-fish (Brachydanio rerio) was determined in a supportive non-GLP study (Ciba-Geigy, 1988). In this study test organisms were exposed to test item at nominal concentrations of 0 (control, solvent control), 1.8, 3.2, 5.8, 10, 18, 32, 58 and 100 mg/L for 96-h under static conditions. The 96-h LC50 was 83 mg/L. The LC0 was 18 mg/L. However, high vehicle concentration was used and undissolved test item was observed in concentrations above 18mg/L and observed adverse effect could relate to this fact.
Thus, it can be concluded that the test substance is not acutely toxic to fish at the range of solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
