Pyridine

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

other: handbook

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data obtained from a reliable handbook of toxicology.

Data source

Reference

Reference Type:

review article or handbook

Title:

Heterocyclic and Miscellaneous Nitrogen Compounds

Author:

Trochimowicz HL

Year:

1994

Bibliographic source:

in Patty's Industrial Hygiene and Toxicology, 4th Ed. (GD Clayton and FE Clayton, eds), New York, John Wiley and Sons

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: similar to OECD acute toxicity guidelines

Principles of method if other than guideline:

Unknown method, as provided in a reputable textbook. We defer to the editors of the textbook to ensure that valid methods were used to generate this data. Handling experience with this value has not resulted in the questioning of its accuracy.

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Pyridine

EC Number:

203-809-9

EC Name:

Pyridine

Cas Number:

110-86-1

Molecular formula:

C5H5N

IUPAC Name:

pyridine

Administration / exposure

Route of administration:

intravenous

Vehicle:

not specified

Doses:

no data

No. of animals per sex per dose:

no data

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

360 mg/kg bw

Based on:

test mat.

Applicant's summary and conclusion

Conclusions:

The LD50 of pyridine administered to rats by the intravenous route was reported to be 360 mg/kg bw.