Registration Dossier
Registration Dossier
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EC number: 202-592-8 | CAS number: 97-59-6
Carcinogenicity
Administrative data
Description of key information
There were no significant differences in survival between the treated groups and their controls. The following table depicts the incidence of tumors in rats given feed supplemented with Allantoin for 106 weeks and in control rats:
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the weight of evidence, Allantoin does not meet the criteria for classification as a carcinogen according to EU Directive 67/548/EEC and Regulation 1272/2008.
Additional information
The study was not performed according to OECD guidelines, however, the study was conducted by a reputable U.S. Governmental laboratory and published as a peer-reviewed paper in a renowned journal. Therefore it is considered to be sound and rated reliable with restrictions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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