Registration Dossier
Registration Dossier
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EC number: 223-055-4 | CAS number: 3710-84-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-guideline study with limited details
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
- Principles of method if other than guideline:
- Draize Test
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N-diethylhydroxylamine
- EC Number:
- 223-055-4
- EC Name:
- N,N-diethylhydroxylamine
- Cas Number:
- 3710-84-7
- Molecular formula:
- C4H11NO
- IUPAC Name:
- N,N-diethylhydroxylamine
- Details on test material:
- - Name of test material (as cited in study report): Diethylhydroxylamine #2049
- Analytical purity: no data
- Lot/batch No.: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 3 days
- Number of animals:
- 6
- Details on study design:
- One-half ml was applied to one intact and abraded skin site under standard gauze patches on each of six albino rabbits. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 24 hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No signs of irritation were discernible at any of the twelve treated skin sites.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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