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EC number: 425-180-1 | CAS number: 66170-10-3
Endpoint summary
Administrative data
Description of key information
A oral and a dermal acute toxicity study were conducted with Sodium ascorbyl phosphate. Both limit studies showed no mortality, no body weight change and only very weak transient clinical symptoms.
No acute toxicity studies for inhalative administration are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral route:
In an acute oral toxicity study (BASF AG, 1997), one group of fasted, young adult Wistar rats (5/sex) were given a single oral dose of Sodium Ascorbyl Phosphate (85.4 %) in water at a dose of 5000 mg/kg bw and observed for 14 days.
Oral LD50:
Males > 5000 mg/kg bw
Females > 5000 mg/kg bw
Combined > 5000 mg/kg bw
No mortality occurred in this limit test. Sodium Ascorbyl Phosphate is of low Toxicity based on the LD50 in male and female rats. Weak and only transient clinical signs observed were: Impaired general state, Poor general state, Dyspnoea, Apathy, Staggering, Piloerection , Diarrhea. There were no treatment related necropsy findings or changes in body weight.
Dermal route:
In an acute dermal toxicity study (BASF AG, 1998), one group of young adult Wistar rats (5 /sex) were dermally exposed to Sodium ascorbyl phosphate (85.4 % in water) for 24 hours to at least 10 % of body surface are at a limit dose of 2000 mg/kg bw. Animals then were observed for 14 days.
Dermal LD50:
Males > 2000 mg/kg bw
Females > 2000 mg/kg bw
Combined > 2000 mg/kg bw
No mortality occurred in this limit test. Sodium ascorbyl phosphate is of low toxicity based on male and female animals. Only very slight erythema was observed on day 1 in some animals. There were no treatment related clinical signs, necropsy findings or changes in body weight.
Justification for classification or non-classification
Based on the results for oral and dermal acute toxicity (no mortality at limit doses, only weak clinical signs) Sodium ascorbyl phosphate is not classified according to EU Directive 67/548/EC amended and repealed by EU Regulation No.1272/2008 and CLP.
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