2-imidazolidone

Toxicity to other above-ground organisms

Administrative data

Endpoint:

toxicity to other above-ground organisms

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

unsuitable test system

Data source

Reference

Reference Type:

publication

Title:

Studies on the mode of action of the chemosterilants 2-Imidazolidinone and 4-Imidazolidin-2-one in the house fly and in the large milkweed bug

Author:

Schaefer C.H.

Year:

1967

Bibliographic source:

Life Sciences Vol . 6, pp. 2677-2683, 1967

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

One-day-old adult female house flies and large milkweed bugs were injected with one µL of an aqueous solution containing 5 µL of 2-imidazolidinone or 4-imidazolin-2-one. Ten insects per treatment were held in a 125 mL Erlenmeyer flask and covered with cheesecloth. All treatments and analyses were made in duplicate.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-imidazolidone

EC Number:

204-436-4

EC Name:

2-imidazolidone

Cas Number:

120-93-4

Molecular formula:

C3H6N2O

IUPAC Name:

2-imidazolidone

Test material form:

solid

Sampling and analysis

Analytical monitoring:

yes

Test substrate

Vehicle:

no

Test organisms

Test organisms (species):

other: House Fly and Large Milkweed Bug

Study design

Study type:

laboratory study

Limit test:

yes

Total exposure duration:

24 h

Test conditions

Details on test conditions:

- Animals per treatment: 10
- Test vessel: 125 mL Erlenmeyer flask covered with cheesecloth
- Number of replicates: 2

Nominal and measured concentrations:

The animals were injected with 5 µg/µL of the test substance.

Results and discussion

Effect concentrations

Effect concentrations 1

Key result

Duration:

24 h

Dose descriptor:

other: Average metabolism of test substance

Effect conc.:

68 other: %

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Remarks on result:

other: Adult House Fly

Effect concentrations 2

Key result

Duration:

24 h

Dose descriptor:

other: Average metabolism of test substance

Effect conc.:

0 other: %

Nominal / measured:

meas. (arithm. mean)

Conc. based on:

test mat.

Remarks on result:

other: Adult Milkweed Bug

Any other information on results incl. tables

Average excretion and metabolism in house flies and large milkweed bugs 24 hours after the injection of 5 µg per insect:

Species	Quantity (µg) of Sterilant			% of total dose
	Tissues	Feces	Metabolized	Tissues	Feces	Metabolized
Adult House Fly	0.8	0.8	3.4	16	16	68
Adult Large Milkweed Bug	5.0	0.0	0.0	100	0	0

2-Imidazolidinone is a temporary sterilants in house flies (Musca domestica L.), but produce permanent effects in large milkweed bugs (Oncopeltus fasciatus Dallas). Flies are able to eliminate large amounts of the compound through excretion and metabolism, whereas neither method of elimination was found in milkweed bugs.