Ethylenediamine, salt with phosphoric acid

Long-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to fish, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

for read across

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Long term toxicity of test material on fish

GLP compliance:

not specified

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Test type:

flow-through

Water media type:

freshwater

Total exposure duration:

14 d

Reference substance (positive control):

not specified

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

440 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

mortality

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

250 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

mortality

Validity criteria fulfilled:

not specified

Conclusions:

The test material is not likely to be toxic to fish in chronic study . The effect concentration is in the range of 250-440 mg/l for 14 days

Executive summary:

Data available for the functionally similar read across chemicals has been reviewed to determine the long term toxicity of fish of the test chemical .The studies are as mentioned below:

For a functionally similar read across substance, long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 250 mg/l and NOEC was noted at 35 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

For another functionally similar read across substance , long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 440 mg/l and NOEC was noted at 74 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

Description of key information

Long-term toxicity to fish:

Data available for the functionally similar read across chemicals has been reviewed to determine the long term toxicity of fish of the test chemical .The studies are as mentioned below:

For a functionally similar read across substance, long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 250 mg/l and NOEC was noted at 35 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

For another functionally similar read across substance , long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 440 mg/l and NOEC was noted at 74 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

250 mg/L

Additional information

Long-term toxicity to fish:

Data available for the functionally similar read across chemicals has been reviewed to determine the long term toxicity of fish of the test chemical .The studies are as mentioned below:

For a functionally similar read across substance, long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 250 mg/l and NOEC was noted at 35 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.

For another functionally similar read across substance , long term toxicity test of test material was performed for 14 days , The LC 50 for test material observed after 14 days was 440 mg/l and NOEC was noted at 74 mg/l.Based on the above effect concentration it can be considered that test material has no long term toxicity effect on fish , and can be considered to be not classified as per CLP criteria.