Registration Dossier
Registration Dossier
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EC number: 603-266-1 | CAS number: 128286-13-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- slight variations of humidity beyond the norms (30 to 70%RH) with a maximum at 79% RH
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- DiCOA
- IUPAC Name:
- DiCOA
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 10% suspension in a 1% aqueous dispersion of CMC
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- no
- Details on study design:
- main study: test article as a 10% (w/v) suspension, pH=5.2, T=16.6°C
Examinations 15 min after intubation, then at 1, 2 and 4 h then each day for 14 days
Results and discussion
- Preliminary study:
- test article as a 2.5%, 5%, 10% w/v suspension in the vehicle
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality was observed
- Clinical signs:
- other: There were no changes in behavior or clinical signs in any of the treated animals during the observation period.
- Gross pathology:
- There were no macroscopic findings that could be associated with treatment.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50, by the oral route , in the rat (male+female) >2000 mg/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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