Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 221-416-0 | CAS number: 3088-31-1
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Metbolism of the surfactants sodium undecyltriethoxy sulphate and sodium dodecyltriethoxy sulphate in the rat
- Author:
- Taylor, A.J., et al.
- Year:
- 1 978
- Bibliographic source:
- Biochem. J. 174, 405-412
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- EC Number:
- 236-091-0
- EC Name:
- Sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- Cas Number:
- 13150-00-0
- IUPAC Name:
- sodium 2-{2-[2-(dodecyloxy)ethoxy]ethoxy}ethyl sulfate
- Details on test material:
- - Name of test material : sodium 2-[2-[2-(dodecyloxy)ethoxy]ethoxy]ethyl sulphate
- Substance type : Organic
- Physical state : Liquid
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: Oral, intraperitoneal or intravenous
- Vehicle:
- not specified
- Details on exposure:
- Authors studied the metabolic fate of orally, intraperitoneally or intravenously administered 14C-CllAE3S and 14C-C12AE3S in the rat.
- Duration and frequency of treatment / exposure:
- Details not available
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Details not available
- No. of animals per sex per dose / concentration:
- Details not available
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- After oral exposure, the chemical is readily absorbed in the gastrointestinal tract in man and rat. The dermal absorption of the chemical is relatively poor as can be expected from an ionic molecule.
- Type:
- distribution
- Results:
- Since metabolism of the chemical has been reported, it is likely to be distributed in the liver where much of the metabolism takes place.
- Type:
- metabolism
- Results:
- Both compounds were extensively metabolized (omega and beta oxidation) with the proportion of radioactivity appearing in urine and respired air generally independent of the route of administration.
- Type:
- excretion
- Results:
- By the oral route, 67% of the administered radioactivity with CllAE3S appeared in the urine of male rats compared to 45% in females; expired air contained 19% and 35% of administered radioactivity respectively; 4-5% was present in faeces for both sexes.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- 2-(triethoxy sulphate) acetic acid (source chemical - C12AE3S)
3-(triethoxysulfate) propionic acid (source chemical - CllAE3S)
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- The length of the ethoxy1ate portion in an AES molecule seems to have an important impact on the biokinetics of AES in humans and in the rat.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Since the chemicals 14C-CllAE3S and 14C-C12AE3S (AES – Alcohol Ethoxy Sulphates) were readily absorbed in the gastrointestinal tract in man and rat, metabolized and excreted out of the living system through the urine and feaces (longer ethoxylate chains (>7-9 EO units), it can be concluded that they shall exhibit low bio-accumulation potential. - Executive summary:
Since the chemicals14C-CllAE3S and 14C-C12AE3S (AES – Alcohol Ethoxy Sulphates) were readily absorbedin thegastrointestinal tract in man and rat, metabolized and excreted out of the living system through the urine and feaces (longer ethoxylate chains (>7-9 EO units), it can be concluded that they shall exhibit low bio-accumulation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
