Registration Dossier
Registration Dossier
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EC number: 235-468-7 | CAS number: 12237-62-6 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 42535:3.
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two bioaccumulation studies as-
WoE 2. and WoE 3. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish
- Route of exposure:
- aqueous
- Test type:
- not specified
- Water / sediment media type:
- not specified
- Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- WoE 2:
BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 3.28 (estimated value)
WoE 3:
BASIS FOR CALCULATION OF BCF
- Result based on calculated log Pow of: 8.69(estimated value) - Key result
- Type:
- BCF
- Value:
- > 66 - < 500 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- other: Log Pow and a regression derived equation.
- Remarks on result:
- other: WoE 2 and WoE 3
- Validity criteria fulfilled:
- not specified
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain
- Executive summary:
Data available of its read across chemicals has been reviewed to determine the bioaccumulation potential of test chemical. The studies are as mentioned below:
Bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 66 dimesionless, from an estimated log Pow of 3.28 and a regression derived equation.
Another bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 500 dimesionless, from an estimated log Pow of 8.69 and a regression derived equation.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain
Reference
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain
Key value for chemical safety assessment
Additional information
Data available of its read across chemicals has been reviewed to determine the bioaccumulation potential of test chemical. The studies are as mentioned below:
Bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 66 dimesionless, from an estimated log Pow of 3.28 and a regression derived equation.
Another bioaccumulation test was conducted for estimating the bioconcentration factor (BCF) of test chemical.The bioconcentration factor was determined to be 500 dimesionless, from an estimated log Pow of 8.69 and a regression derived equation.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the BCF value of the test chemical can be expected to be in the range 66 to 500 dimensionless, respectively. Thus, as this value does not exceed the bioconcentration threshold of 2000 indicating that the test chemical is not expected to bioaccumulate in the food chain
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