Registration Dossier
Registration Dossier
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EC number: 206-055-9 | CAS number: 298-06-6
Endpoint summary
Administrative data
Description of key information
A study was performed to assess the irritatany potential of Danafloat 123, containing 49.2% EP1-Na, to the skin of rabbits. The method used followed the recommendations of the OECD guideline 404 and Method B4 of Comission Directive 92/69/EEC.
A 4 -hour semi-occluded application of the test material to intact skin produced severe erythema and oedema besides other severe skin reactions. As well, exposure durations of one hour and 3 minutes resulted in well-defined erythema and very slight to slight oedema, loss of skin elasticity, skin discolouration, crust formation and reduced regrowth of fur. On occasions, it was not possible to accurately evaluate the erythema and oedema due to the other skin reactions observed.
The presence of scar tissue at one skin site following a 4 -hour exposure period was indicative of full thickness tissue destruction. The test material was therefore classified as corrosive. Classification according to the Draize system was not applicable.
Based on the results of the skin irritation study which resulted in a classification as corrosive, the eye irritation study is waved with respect to animals welfare.
Key value for chemical safety assessment
Additional information
According to regulation (EC) 1907/2006 of the European parliament and the council of 18 December 2006 (Article 17), no chemical safety assessment is required for on-site isolated intermediates. Therefore, no key values were defined for EP1.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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