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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Draize method
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propane-2-thiol
EC Number:
200-861-4
EC Name:
Propane-2-thiol
Cas Number:
75-33-2
Molecular formula:
C3H8S
IUPAC Name:
propane-2-thiol
Test material form:
liquid
Details on test material:
No details available

Test animals / tissue source

Species:
rabbit
Strain:
other: Albino
Details on test animals or tissues and environmental conditions:
No detail available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0.1 ml
Duration of treatment / exposure:
Not rinsed
Observation period (in vivo):
10 min and 1, 2, 3, 4, 24, 48 and 72 hours
Number of animals or in vitro replicates:
6
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data

SCORING SYSTEM: Draize scale

TOOL USED TO ASSESS SCORE: No data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
animal: 1 to 5
Time point:
24/48/72 h
Score:
0
Max. score:
3
Irritation parameter:
conjunctivae score
Basis:
animal #6
Time point:
24/48/72 h
Score:
0.66
Max. score:
3
Reversibility:
fully reversible within: 72 h
Irritation parameter:
chemosis score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
cornea opacity score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
iris score
Basis:
animal: 1 to 6
Time point:
24/48/72 h
Score:
0
Max. score:
2
Irritant / corrosive response data:
The only effec was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

In a preguideline study, a 0.1 ml dose of iso-propyl mercaptan was instilled into one eye of six rabbits. Irritation was scored at 10 min and 1, 2, 3, 4, 24, 48 and 72 hours. The only effect was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected. The responses recovered within 24 hours in five of six rabbits while the sixth animal recovered within 48 hours. Iso-propyl mercaptan is a slight eye irritant.