Registration Dossier
Registration Dossier
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EC number: 269-789-9 | CAS number: 68333-79-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance has no structural alerts for mutagenicity. Furthermore, in vitro studies from analogous substances were all negative. These studies were performed in accordance with an approved guideline and under the conditions of GLP. All studies were negative both with and without metabolic activation. There is no reason to believe that these results would not be applicable to humans.
Read-across in accordance with Annex XI, Section 1.5 of Regulation (EC) No. 1907/2006 (REACH) is justified on the following basis:
Polyphosphoric acids, ammonium salt (also known as ammonium polyphosphate) is a mixture of oligomeric species of ammonium phosphate. When analysed the substance appears to consist mainly of ammonium orthophosphates, ammonium diphosphate and ammonium triphosphate. Phosphate is not considered to be mutagenic as it is frequently present within the buffers used for in vitro mutagenicity tests (i.e. as sodium or potassium phosphates). Therefore in order to assess the mutagenicity potential of ammonium polyphosphate it is the ammonium ion that is of interest.
As such it is scientifically justified to read-across to other ammonium phosphates. Such as, ammonium dihydrogenorthophosphate and diammonium hydrogenorthophosphate.
Justification for selection of genetic toxicity endpoint
No study was selected since all three in vitro studies were negative.
Short description of key information:
Studies to fulfil each in vitro mutagenicity endpoint are available. All studies are performed in accordance with an approved guideline and under the conditions of GLP. All studies were negative both with and without metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the classification criteria and an assessment of the structure of ammonium polyphosphate the substance is not considered to be mutagenic and no classification is proposed.
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