Registration Dossier
Registration Dossier
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EC number: 215-478-8 | CAS number: 1327-43-1
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
Skin sensitisation
No experimental data are available for silicic acid, aluminium magnesium salt on skin sensitisation. However, according to the OECD guideline 406, the sensitising potential of the compound silicic acid, titanium salt was measured using the guinea pig maximisation test after Magnusson and Kligman (Richeux 2006). No macroscopic cutaneous reactions attributable to allergy were recorded during the examination following the removal of the occlusive dressing (challenge phase) from the animals pre-treated (induced) with the test material. No cutaneous intolerance reaction was recorded in animals from the negative control groups. Historical positive controls showed validity of the test results.
Migrated from Short description of key information:
Under the experimental conditions, silicic acid, titanium salt showed no sensitising potential. Based on structure analogy, no sensitising of the skin is expected to occur likewise from the exposure to silicic acid, aluminium magnesium salt for which corresponding studies are not available.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Not required.
Migrated from Short description of key information:
Not required.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
