Registration Dossier
Registration Dossier
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EC number: 228-058-4 | CAS number: 6104-58-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- Guidelines followed
- GLP compliance:
- no
- Type of method:
- flask method
- Key result
- Water solubility:
- 171 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH is not available
- Details on results:
- None
- Conclusions:
- The water solubility cs of the test item at a temperature of 20 °C was determined to be (without correction for the purity): cs = 171 g/l
- Executive summary:
The water solubility cs of the test item was evaluated in a study conducted according to OECD Guideline 105 and EU Method A.6. Using the flask method, the water solubility for the test item at a temperature of 20 °C was determined to be (without correction for the purity): cs = 171 g/l.
Reference
Individual Results
Preliminary Visual Estimation of the Water Solubility
Table: Appearance of the test mixtures in the preliminary test
| Amount of test item in mg | Total volume in ml | Appearance of mixture |
| 100 | 0.1 | undissolved |
| 100 | 0.5 | undissolved |
| 100 | 1 | dissolved |
The preliminary visual experiments showed that the water solubility of the test item is >100 g/l and <200 g/l . Therefore the water solubility had to bo determined by the “flask method”.
Flask-Method
Table: Water solubility of the test item – experiments A to D
| Experiment | A | B | C | D (blank) |
| Amount of test item (g) | 1 | 1 | 1 | - |
| Stirring time at 30°C (h) | 24 | 48 | 72 | 72 |
| Measured concentration (μg/ml) | 43.9 | 43.3 | 41.6 | - |
| Water Solubility (g/l) | 175 | 173 | 166 | - |
Average experiments A to C: 171 g/l
Standard deviation: 4.3 g/l
Relative standard deviation: 2.5 %
The recovery was estimated to be 102.9 %, which indicates a sufficient accuracy of the analytical method.
Description of key information
The water solubility cs of the test item at a temperature of 20 °C was determined to (without correction for the purity): cs = 171 g/l.
Key value for chemical safety assessment
- Water solubility:
- 171 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility cs of the test item was evaluated in a study conducted according to OECD Guideline 105 and EU Method A.6. Using the flask method, the water solubility for the test item at a temperature of 20 °C was determined to be (without correction for the purity): cs = 171 g/l.
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