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EC number: 200-353-2 | CAS number: 57-88-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
OECD 302C (Modified MITI (II) test): 74% degradation in 28 days
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable
Additional information
An OECD 302C (Modified MITI (II)) test was performed with the test substance with a concentration of 30 mg cholesterol/L. The biodegradation of the test substance was followed by BOD measurements. Cholesterol was found to biodegrade for 67% in 14 days and 74% in 28 days, thus showing inherent biodegradability.
Additionally, a study was performed to examine the transformation products of radiolabelled cholesterol during simulated laboratory-based aerobic sewage treatment (semi-continuous activated sludge (SCAS) and die away (DA) methods) using 14C-cholesterols radiolabelled at positions 4 or 26. Mineralisation of cholesterol was determined to be 49% in 92 hr, consistent with A-ring rupture (rather than aromatisation) and beta-oxidation of the alkyl side chain as major transformation routes. Another publication showed the biodegradation of a substance similar to cholesterol ( 7-ketocholesterol) by different types of microorganisms. The test results showed that extensive mineralization of the substance took place within a short timeframe (14 -43% in 12.5 days).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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