Naphthalenesulfonic acid, di-C9-rich C8-10-branched alkyl derivs., calcium salts

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: An appropriate number of animals were exposed to a concentration (~18 mg/L) greatly exceeding the standard limit concentration (5 mg/L).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: FHSLA, CFR, Title 21 J para. 191.10.

Deviations:

not specified

GLP compliance:

no

Test type:

fixed concentration procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Calcium bis(di C8-C10, branched, C9 rich, alkylnaphthalene sulphonate)

Molecular formula:

[C26H39SO3]2Ca to [C30H47SO3]2Ca

IUPAC Name:

Calcium bis(di C8-C10, branched, C9 rich, alkylnaphthalene sulphonate)

Test material form:

liquid: viscous

Details on test material:

A dark brown viscous liquid identified as NASUL 729

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

A group of five male and five female Wistar rats were exposed to the test
material.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

not specified

Details on inhalation exposure:

Rats were exposed to NASUL 729 (vaporized) in an inhalation chamber for 1 hour. The chamber was saturated with
18 mg/liter nominal of the test material prior to the period of exposure.
The rats were observed for 14 days following exposure. Feed and water were provided ad libitum.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

ca. 1 h

Concentrations:

18 mg/liter nominal

No. of animals per sex per dose:

5 male and 5 female rats

Control animals:

no

Statistics:

None required. No mortality.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 18 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

1 h

Mortality:

No mortality.

Clinical signs:

other: No untoward reactions.

Body weight:

See table.

Gross pathology:

None reported.

Any other information on results incl. tables

Rat No.	Sex	Body Weight - grams	Mortality
1	M	229	No
2	M	265	No
3	M	229	No
4	M	256	No
5	M	263	No
6	F	291	No
7	F	271	No
8	F	256	No
9	F	261	No
10	F	278	No

Applicant's summary and conclusion

Interpretation of results:

other: relatively harmless

Conclusions:

The Inhalation LC50 of rats exposed for 1 hour to the test material is greater than 18 mg/liter.

Executive summary:

A group of five male and five female Wistar rats were exposed to NASUL 729. The rats were exposed to NASUL 729 (vaporized) in an inhalation chamber for 1 hour. The chamber was saturated with 18 mg/liter nominal of the test material prior to the period of exposure. The rats were observed for 14 days following exposure. Feed and water were provided ad libitum. No mortalities or clinical symptoms observed. The Inhalation LC50 of rats exposed for 1 hour to the test material is greater than 18 mg/liter. On an active ingredient basis the LC50 > 9 mg/L.