Registration Dossier
Registration Dossier
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EC number: 931-740-0 | CAS number: -
Toxicity to other aquatic organisms
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of the substance to Vibrio fisheri was determined by using the ISO Guideline 11348-3. The study was conducted in a laboratory where principles of Good Laboratory Practice have been introduced, but this study was not conducted in a compliance with GLP. As the substance is a UVCB- substance, there are differences in the partitioning behavior and water solubility between the constituents. Therefore, water accommodated fractions (WAFs) were prepared, and the exposure was expressed as the loading rates (mass to volume ratio of the mixture to medium). The inhibition of bioluminescence was calculated after 15 minutes and 30 minutes of exposure and toxicity was expressed as the EL50 and EL10 values.
Additional information
The acute toxicity of the substance on marine bacteriaVibrio fisheriwas carried out according to the ISO Guideline 11348-3.
The substance is a UVCB- substance. Due to differences in partitioning behavior and water solubility between the components, it is difficult to achieve a homogeneous solution by direct addition of the test substance into the test medium. Therefore water accommodated fractions (WAFs) were prepared. The WAF of the multi-component substances contains only the fraction that is dissolved or present as a stable dispersion or emulsion. The exposure was expressed as the loading rate (mass to volume ratio of the mixture to medium).
The inhibition of bioluminescence was calculated after 15 minutes and 30 minutes of exposure and toxicity was expressed as the EL50 and EL10- values. The luminescent bacteria test was used as an additional toxicity screening method for the substance in order to have an estimate on the acute aquatic toxicity. Because of the short incubation time in comparison with the more preferable methods such as fish, algae and D. magna tests, this study was used in order to avoid reduction of the substance concentration by evaporation during testing. In addition, the Vibrio fisheri assay is known to be especially sensitive for organic contaminants.
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