Registration Dossier
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EC number: 297-443-7 | CAS number: 93572-14-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic invertebrates up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the short-term toxicity of Fatty acids, soya, 2-ethylhexyl
esters (CAS 93572-14-6) to aquatic invertebrates are not available.
The assessment was therefore based on studies conducted with the
structurally analogue substances 2-ethylhexyl oleate (CAS 26399-02-0)
and Fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2), as part
of a read across approach, which is in accordance with Regulation (EC)
No. 1907/2006, Annex XI, 1.5. Further justification is given within the
overall summary chapter 6.1 and within the analogue justification
section 13.
The short-term toxicity of 2-ethylhexyl oleate (CAS 26399-02-0) was
tested according to the EU-method C.2 considering the VCI concept draft
for the acute testing of poorly soluble substances from 1994-01-31. In a
first approach insoluble substance particles were not removed from the
test solution. After an exposure period of 48 hours immobilization rates
ranging from 0 to 100% (mean: 25%) were observed. In a second approach
insoluble particles were removed from the test solution by filtration.
Effects on Daphnia magna were not observed. Thus, the observed
immobilization of the Daphnids was presumably due to physical effects
(e.g. agglutination of gills). Therefore an EC50 (48h) > 100 mg/L
(nominal) was determined. The toxicity of Fatty acids, C8-16,
2-ethylhexyl esters (CAS 135800-37-2) to Daphnia magna was investigated
in a study following EU-method C.2 (Wierich, 1998). The study was set up
as a static test under GLP conditions. The toxicity of the substance was
tested in two approaches. In a first approach the test solution was not
filtered and undissolved test remained in the solution, whereas in a
second approach the test solution was filtered. The substance
concentration of both test solutions was determined analytically. In the
unfiltered test solution (12.41 mg/L, measured) an average of 50% of the
test animals was immobilized by physical effects. No effects on the
mobility were observed in the filtered test solutions (0.04 mg/L,
measured). Thus an EC50(48h) >100 mg/L (nominal) was reported.
Thus, based on the above mentioned result, and due to the structural and
profile similarities of the substances, as are explained with in the
overall endpoint summary 6.1 it can be concluded that no toxicological
effects on aquatic invertebrates are expected up to the limit of water
solubility for Fatty acids, soya, 2-ethylhexyl esters (CAS 93572-14-6).
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