Registration Dossier
Registration Dossier
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EC number: 618-295-5 | CAS number: 897626-46-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects up to the limit of water solubility (< 0.004 mg/L in aqua dest) for Cyprinus carpio (OECD 203)
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of Bis(2-octyldodecyl) azelate (CAS 897626-46-9) to freshwater fish are available for this endpoint, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related category members Bis(2-ethylhexyl) azelate (CAS 103-24-2) and Di(2-octyldodecyl) sebacate (CAS 69275-01-0) was conducted. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance within this category was used.
Short term toxicty to Bis(2-ethylhexyl) azelate was investigated according to OECD 203 under static conditions using Cyrinus carpio as test organism (Bogers, 1998). Siphoned test solutions in concentrations of 1 to 1000 mg/L were applied. The appearance of the final test solutions ranged from clear and colourless to turbid at the higher test concentrations. A 96 h-LC50 value of > 10000 mg/L is determined on the basis of the nominal concentration. As observed undissolved test material was not removed from the treatments, adverse effects could either be caused by systemic toxicity or by physical interferences. However, as no mortality was observed in any treatment the test can be considered as appropriate to assess the hazard of the substance to fish.
A supporting study with Di(2-octyldodecyl) sebacate (CAS 69275-01-0) confirmed this result.This semi-static study was performed according to GLP and ISO guideline 7346/1-3 using Brachydanio rerio as test organism (Gode, 1986). No mortality is observed in the control and the 100 mg/L treatment throughout the test period of 96 h. Hence, the 96 h-LC50 is determined to be > 100 mg/L based on the nominal test concentration.
Due to the structural and property similarities with the tested category members Bis(2-ethylhexyl) azelate (CAS 103-24-2) and Di(2-octyldodecyl) sebacate (CAS 69275-01-0) these results are also applicable to read across to Bis(2-octyldodecyl) azelate (CAS 897626-46-9).
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