Registration Dossier

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in chemico
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15.11.2018 - 30.11.2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2019

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of study:
direct peptide reactivity assay (DPRA)

Test material

Constituent 1
Chemical structure
Reference substance name:
(E,E,E)-2,7-dimethylocta-2,4,6-trienedial
EC Number:
225-756-0
EC Name:
(E,E,E)-2,7-dimethylocta-2,4,6-trienedial
Cas Number:
5056-17-7
Molecular formula:
C10H12O2
IUPAC Name:
(E,E,E)-2,7-dimethylocta-2,4,6-trienedial
Test material form:
liquid

In chemico test system

Details on the study design:
see OECD 442c

Results and discussion

In vitro / in chemico

Results
Key result
Vehicle controls validity:
valid
Negative controls validity:
valid
Positive controls validity:
valid
Remarks on result:
positive indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
Category 1A (indication of significant skin sensitising potential) based on GHS criteria
Conclusions:
In this study under the given conditions the test item showed high reactivity towards both peptides. The test item is considered as “sensitiser”.
Executive summary:

In this study under the given conditions the test item showed high reactivity towards both peptides. The test item is considered as “sensitiser”.