Registration Dossier
Registration Dossier
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EC number: 225-756-0 | CAS number: 5056-17-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15.11.2018 - 30.11.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- direct peptide reactivity assay (DPRA)
Test material
- Reference substance name:
- (E,E,E)-2,7-dimethylocta-2,4,6-trienedial
- EC Number:
- 225-756-0
- EC Name:
- (E,E,E)-2,7-dimethylocta-2,4,6-trienedial
- Cas Number:
- 5056-17-7
- Molecular formula:
- C10H12O2
- IUPAC Name:
- (E,E,E)-2,7-dimethylocta-2,4,6-trienedial
- Test material form:
- liquid
Constituent 1
In chemico test system
- Details on the study design:
- see OECD 442c
Results and discussion
In vitro / in chemico
Results
- Key result
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- positive indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (indication of significant skin sensitising potential) based on GHS criteria
- Conclusions:
- In this study under the given conditions the test item showed high reactivity towards both peptides. The test item is considered as “sensitiser”.
- Executive summary:
In this study under the given conditions the test item showed high reactivity towards both peptides. The test item is considered as “sensitiser”.
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