Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-688-5 | CAS number: 124-19-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In vitro gene mutation studies in bacteria concluded that the test substance was not genotoxic under the conditions of the studies either with or without metabolic activation.
An in vitro mouse lymphoma study was negative with and without metabolic activation.
There was a negative results for an in vitro unscheduled DNA synthesis assay, however whilst a chromosome aberration assay was negative, a sister chromatid exchange assay was positive.
The results of an in vivo mouse micronucleus study conducted according to OECD guideline 474 on a structural analogue did not show any evidence of causing chromosome damage when administered orally.
Justification for selection of genetic toxicity endpoint
The results of an in vivo mouse micronuclus study conducted
according to OECD guideline 474 on a structural analogue did not show
any evidence of causing chromosome damage when administered orally.
Short description of key information:
In vitro gene mutation studies in bacteria concluded that the test
substance was not genotoxic under the conditions of the studies either
with or without metabolic activation.
An in vitro mouse lymphoma study was negative without metabolic
activation but positive with metabolic activation.
There was a negative results for an in vitro unscheduled DNA synthesis
assay, however whilst a chromosome aberration assay was negative, a
sister chromatid exchange assay was positive.
The results of an in vivo mouse micronucleus study conducted according
to OECD guideline 474 on a structural analogue did not show any evidence
of causing chromosome damage when administered orally.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The results of an in vivo mouse micronucleus assay conducted according to OECD guideline 474 on a structural analogue did not show any evidence of causing chromosome damage when administered orally.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
