Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 606-280-6 | CAS number: 192704-54-4
Endpoint summary
Administrative data
Description of key information
Oral (Rat, OECD TG 423): LD50 > 2000 mg/kg
[Schering AG, Report No. X549 -draft-, 2001-03-26]
Dermal (Rat, OECD TG 402): LD50 > 2000 mg/kg
[Schering AG, Report No. X525 -draft-, 2001-02-08]
Key value for chemical safety assessment
Additional information
The single oral administration of the test substance (ZK 233744) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs or effects on body weight were observed and there were no macroscopic pathological signs.
The acute oral toxicity of Diketon in rats is therefore above 2000 mg/kg body weight.
The single dermal administration of the test substance (ZK 233744) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality, clinical signs or findings at necropsy. The body weight of one male decreased in week 1 and this male showed a reduced body weight gain throughout the whole study period, when compared to the 90% range of historical reference data used in the study performing laboratory. As all other animals did not show any effect on the body weight, the significance of the finding remains unclear.
The acute dermal toxicity of Diketon in rats is therefore above 2000 mg/kg body weight.
Moreover, no compound-related local findings were observed. The mean values of findings at the time-points 24, 48 and 72 h after administration were 0 for swelling, reddening and scab formation.Justification for classification or non-classification
Based on the study results a classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
