Registration Dossier
Registration Dossier
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EC number: 216-629-0 | CAS number: 1630-78-0
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental start date: 26 March 2020; Experimental completion date: 28 April 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Conventional test methods (flask method/column elution method) are not appropriate for highly volatile test items. A modified procedure was therefore adopted.
- Specific details on test material used for the study:
- Identity: TKN1
Batch number: N1200213
Physical state/appearance: Colourless gas
Purity: 100%
Storage conditions: Room temperature
Expiry date: 10 August 2022 - Key result
- Water solubility:
- 2 g/L
- Conc. based on:
- test mat.
- Incubation duration:
- 4 h
- Temp.:
- 20 °C
- pH:
- >= 6.8 - <= 6.9
- Details on results:
- The detector calibration was found to be linear over the range 0 to 260 mg/L with a regression coefficient of 0.9987.
Acceptable mean recoveries of approximately 105 and 76% of TKN1 from fortified samples were achieved at both the high and LOQ levels, respectively. - Conclusions:
- TKN1 was found to have a water solubility of 2.0 g/L at 20°C.
- Executive summary:
TKN1 was found to have a water solubility of 2.0 g/L at 20°C, following a modified procedure designed to be comptible with OECD 105 and EC Method A.6.
Reference
Measurement of Water Solubility at 20°C
Sample |
Time (hours) |
Concentration |
Mean |
|
number |
|
(mg/L) |
concentration |
pH |
|
|
|
(mg/L) |
|
|
|
|
|
|
1A, 1B |
1 |
2030, 2040 |
2030 |
6.9 |
2A, 2B |
2 |
2040, 2020 |
2030 |
6.8 |
3A, 3B |
3 |
1990, 1960 |
1970 |
6.8 |
4A, 4B |
4 |
1920, 1930 |
1930 |
6.8 |
|
|
|
|
|
Overall water solubility= 1990 ± 49 mg/L (RSD = 2.4%)
Description of key information
TKN1 was found to have a water solubility of 2.0 g/L at 20°C, following a modified procedure designed to be compatible with OECD 105 and EC Method A.6.
Key value for chemical safety assessment
- Water solubility:
- 2 g/L
- at the temperature of:
- 20 °C
Additional information
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