Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Test dates: Apr.19 to Jul.5, 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP, but the result is slightly out of the applicability range of the method. The substance is adequately identified. Therefore validation applies with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Deviations:
- yes
- Remarks:
- flask method is recommended for logKow up to 4
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Remarks:
- GIPC; effective Jun.14, 2012, signed on Jan.10, 2013
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Storage conditions of test material: At room temperature protected from direct sunlight.
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 4.98
- Temp.:
- 20 °C
- pH:
- 7.3
- Conclusions:
- The substance has potential to bioaccumulate in the environment, according to CLP classification
criteria for aquatic chronic toxicity (log Kow >4). - Executive summary:
The partition coefficient of the test substance was determined under GLP according to EU A.8 guideline, shake flask method.
Determinations were conducted in duplicate for three solvents ratio (2:40, 1:40, 4:40, 2 replicates each),
concentrations were measured using a GC-FID validated method. Individual results fulfilled the validity
criteria for reproducibility, and mass balance was satisfactory, so the average value is retained.
The log Pow was determined to be 4.98 (at 20°C and pH=7.3).
Reference
| ratio | 1:20 | 1:40 | 1:10 | |||
| replicate vessel | 1 | 2 | 1 | 2 | 1 | 2 |
| log Kow | 5.01 | 5.01 | 5.02 | 4.91 | 4.98 | 4.94 |
| mass balance | 101.9% | 103.9% | 105.2% | 101.7% | 106.6% | 107.4% |
Mean Log Pow and SD = 4.98 +/- 0.04.
The validity criteria were fulfilled: the six LogPow values fell within a range of ± 0.3 units.
The pH of the water phase was measured as 7.3.
Description of key information
Partition coefficient (log Kow) = 4.98 (20°C, pH 7.3) (EU A8, flask; GLP)
The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.
The substance has potential for bioaccumulation (log Kow >4).
It is also of concern for PBT assessment (logKow >4.5).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.98
- at the temperature of:
- 20 °C
Additional information
A reliable experimental study, conducted according to a recognized EC method and under GLP, is available. Despite restrictions on the applicability range of the method used, it is considered as a key study, and the result is retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
