Registration Dossier
Registration Dossier
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EC number: 202-295-3 | CAS number: 94-02-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 08 April 1991
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 24 February 1987
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
Test material
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Group I: 3330 mg/ kg bw
Group II: 5550 mg/ kg bw
Group III: 8325 mg/ kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
- Preliminary study:
- Design: Test with a dose of 5550 mg/ kg bw was conducted on two female rats
Result: No deaths
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 639 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Mortality after 14 days:
Group I: m 0/5, f 1/5
Group II: m 2/5, f 1/5
Group III: m 4/5, f 5/5 - Clinical signs:
- other: Group I: decreased: activity increased: squatting positions reversible within 24 h after treatment Group II: decreased: activity/ body tone/ skin turgor/ plantary reflex increased: abnormal gait/ ventral position/ squatting position/ abnormal body postur
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 > 5000 mg/ kg bw
non-toxic
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