α,α,α-trifluorotoluene

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1986

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1968

Materials and methods

Principles of method if other than guideline:

The test item was applied intraperitoneally to the stomach in pure form and all treated animals were observed for 14 days after the administration.

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

α,α,α-trifluorotoluene

EC Number:

202-635-0

EC Name:

α,α,α-trifluorotoluene

Cas Number:

98-08-8

Molecular formula:

C7H5F3

IUPAC Name:

α,α,α-trifluorotoluene

Test animals

Species:

mouse

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 25 - 30 g

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

unchanged (no vehicle)

No. of animals per sex per dose:

6 mice per dose

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

10 000 mg/kg bw

Based on:

test mat.

95% CL:

>= 7 642 - <= 13 400

Mortality:

No mortality was reported.

Clinical signs:

No signs of toxicity were reported.

Applicant's summary and conclusion

Conclusions:

The oral LD50 to mice was determined to be 10000 mg/kg bw.

Executive summary:

In a published study, the test item was applied intraperitoneally to the stomach of mice in pure form and all treated animals were observed for 14 days after the administration. The LD50 was determined to be 10000 mg/kg bw.