Registration Dossier
Registration Dossier
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EC number: 286-249-8 | CAS number: 85203-56-1 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Eucalyptus maculata citriodora, Myrtaceae.
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- other: constituent classification data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- ECHA database
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Calculation of classification for eye irritation
- Author:
- Royal HaskoningDHV
- Year:
- 2 017
- Bibliographic source:
- Not relevant
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The classification of constituents of Eucalyptus Citriodora was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/damage.
- GLP compliance:
- no
Test material
- Reference substance name:
- Eucalyptus citriodora
- IUPAC Name:
- Eucalyptus citriodora
- Reference substance name:
- 85203-56-1
- Cas Number:
- 85203-56-1
- IUPAC Name:
- 85203-56-1
- Details on test material:
- - Name of test material (as cited in study report): Eucalyptus citriodora
- Physical state: Liquid
- Analytical purity: Confidential information
- Lot/batch No.: Confidential information
- Expiration date of the lot/batch: Confidential information
- Storage condition of test material: Room temperature in the dark
Constituent 1
Constituent 2
Results and discussion
In vitro
Results
- Remarks on result:
- other: Not relevant
In vivo
Results
- Remarks on result:
- other: Not relevant
Any other information on results incl. tables
The most important constituent with regard to eye irritation/eye damage was determined to be 1,(+)-Citronellal (CAS 2385-77-5), which is present in a typical concentration of 76% and is classified for serious eye irritation (Eye Irrit. 2 / H319).
Applicant's summary and conclusion
- Interpretation of results:
- other: Serious eye irritation
- Remarks:
- based on CLP criteria
- Conclusions:
- The major constituent Citronellal is classified for serious eye irritation and is present well above the classification threshold of 10% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Eucalyptus Citriodora is also considered to be classified for serious eye irritation (Eye Irrit. 2 / H319).
- Executive summary:
The classification of constituents of Eucalyptus Citriodora was studied (ECHA website) and used to derive a classification for the UVCB itself using the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) for eye irritation/damage. The most important constituent with regard to eye irritation/eye damage was determined to be1,(+)-Citronellal (CAS 2385-77-5), which is present in a typical concentration of 76% and is classified for serious eye irritation (Eye Irrit. 2 / H319). This is well above the classification threshold of 10% for mixtures, as given in the CLP Regulation (1272/2008/EC). Based on this information, Eucalyptus Citriodora is also considered to be classified for serious eye irritation (Eye Irrit. 2 / H319).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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