Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 915-277-1 | CAS number: 32052-51-0
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: handbook data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Isocyanate / Ullmanns Encyklopädie der technischen Chemie, 4th Ed.
- Author:
- Eisenmann KH and Zenner KF
- Year:
- 1 977
- Bibliographic source:
- VCH-Verlagsgesellschaft, Weinheim, 13, 347-358
Materials and methods
- Type of study / information:
- general toxicological effects
Test material
- Reference substance name:
- Trimethylhexa-1,6-diyl diisocyanate
- EC Number:
- 249-151-6
- EC Name:
- Trimethylhexa-1,6-diyl diisocyanate
- Cas Number:
- 28679-16-5
- Molecular formula:
- C11H18N2O2
- IUPAC Name:
- 1,6-Diisocyanatotrimethylhexane
Constituent 1
Results and discussion
Any other information on results incl. tables
When in contact with biological material, the C=N=O-group of isocyanates reacts predominantly with "active" hydrogen atoms of OH- or NH2 -groups of proteins causing irritation or necrotic effects in cells and tissues. These reactions possibly lead to symptoms like caughing, trachitis, bronchitis and, in some cases, bronchopneumia after inhalatory exposure. Upon short-term exposure of skin or mucosae to isocyanates, only reversible local irritation is to be expected.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
