Registration Dossier
Registration Dossier
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EC number: 451-490-1 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-h LC50 is 40 mg/L in zebra fish.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 40 mg/L
Additional information
The acute toxicity of the test substance to fish was determined in a GLP-compliant test according to the OECD Guideline 203 (RCC, 2005).
In this study, Zebrafish (D. rerio; 7 per concentration) were exposed to nominal concentrations of 0, 4.6, 10, 46 and 100 mg /L for 96 hours under static conditions. Test substance recovery was in the range of 95 -100% of nominal values.
In the control and at the test concentrations up to and including 10 mg/L all fish survived until the end of the test and no visible abnormalities were observed at the test fish. At the next higher test concentration of 22 mg/L visible abnormalities were observed at the test fish, however, all fish survived until the end of the test at that test concentration. First mortality was observed at the test concentration of 46 mg/L (5 of 7 test fish dead at test end) and at the highest test concentration of 100 mg/L all test fish were dead at the observation after 24 hours.
Based on these findings, the 96 -h LC50 value was determined at 40 mg/L (nominal).
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