Registration Dossier
Registration Dossier
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EC number: 231-157-5 | CAS number: 7440-47-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data was available on sensitisation testing with chromium metal. An OECD 406 guideline test with basic chromium(III) sulphate did not cause any skin sensitisation. Read-across to this more soluble Cr(III) compound can be done, in order to show the results of a "worst case" test. As this soluble trivalent chromium compound is not sensitising, it is highly unlikely that the poorly soluble chromium metal would cause skin sensitisation.
The sensitisation potential of metals depends on the amount released and the reaction between the released metals and sweat.
In vitro tests have shown very low release rates of chromium from chromium metal, and also from ferrochromium, ferrosilicochromium and stainless steel. This is due to the oxide layer, which is automatically formed at the surface, thus protecting the metal/alloy from corrosion.
Chromium-containing alloys have been widely used for a long time (for example in stainless steels) and there are no indications of sensitsation even after long-term exposure, like in patients with hip arthroplasties. Also patch-tests with stainless steel do not give positive results in chromium or nickel sensitised individuals.
No released Cr(VI) has been detected in any release tests.
Migrated from Short description of key information:
There are no cases of skin sensitisation caused by chromium metal. A GLP sensitisation test with trivalent basic chromium sulphate did not show any signs of skin sensitisation. A recent evaluation by WHO concluded that water-insoluble chromium(III) oxide does not cause skin sensitisation.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Migrated from Short description of key information:
There are no cases of respiratory sensitisation caused by chromium metal or trivalent chromium compounds.
Justification for classification or non-classification
No classification is suggested.
There are no indications that chromium metal or Cr(III) would cause sensitisation. No Cr(VI) has been detected in chromium metal release tests.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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