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EC number: 249-978-2 | CAS number: 29964-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OSHA Toxicity Screening Test. Limited documentation of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Guideline:
- other: OSHA Toxicity Screening Test
- Principles of method if other than guideline:
- Draize Scoring
- GLP compliance:
- no
Test material
- Reference substance name:
- Isodecyl methacrylate
- EC Number:
- 249-978-2
- EC Name:
- Isodecyl methacrylate
- Cas Number:
- 29964-84-9
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 2-methylnonyl 2-methylprop-2-enoate
- Details on test material:
- 2-Propenoic acid, 2-methyl-, isodecyl ester purity not specified, but commercial grade assumed.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: mean value 2,5 kg
- Housing: single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ±1°C
- Humidity (%): 50 - 60 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hrs dark / 12 hrs light
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: shaved and shaved/abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- undiluted, 3000 mg/kg body weight
- Duration of treatment / exposure:
- no substance removal reported
- Observation period:
- 24h and 72h post application and after 14 days
- Number of animals:
- 6
- Details on study design:
- SCORING SYSTEM:
Erythema and Eschar Formation
No erythema: 0
Very slight erythema (barely perceptible): 1
Well defined erythema: 2
Moderate to severe erythema: 3
Very severe erythema (beef redness) to eschar formation preventing grading of erythema: 4
Maximum possible: 4
Edema Formation
No edema: 0
Very slight edema (barely perceptible) : 1
Slight edem (edges of area well defined by definite raising):2
Moderate edema (raised approximately 1mm): 3
Severe edema (raised more than 1mm and extending beyond area of exposure):4
Maximum possible: 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2, #4
- Time point:
- other: mean 24 + 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Occlusive, exposure during whole observation (not washed) , observation time 72 h, intact skin, reevaluated acc. CLP criteria
- Irritation parameter:
- erythema score
- Basis:
- animal: #3, #5, #6
- Time point:
- other: mean 24 + 72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: Occlusive, exposure during whole observation (not washed) , observation time 72 h, intact skin, reevaluated acc. CLP criteria
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2, #4
- Time point:
- other: mean 24 + 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Occlusive, exposure during whole observation (not washed) , observation time 72 h, intact skin, reevaluated acc. CLP criteria
- Irritation parameter:
- edema score
- Basis:
- animal: #3, #5, #6
- Time point:
- other: mean 24 + 72 hours
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Remarks on result:
- other: Occlusive, exposure during whole observation (not washed) , observation time 72 h, intact skin, reevaluated acc. CLP criteria
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: avaraged score for 24 and 72 hrs; shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: avaraged score for 24 and 72 hrs; shaved skin
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: avaraged score for 24 and 72 hrs; shaved skin
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: avaraged score for 24 and 72 hrs; shaved skin
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: avaraged score for 24 and 72 hrs; shaved skin
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: avaraged score for 24 and 72 hrs; shaved skin
Any other information on results incl. tables
Isodecyl methacrylate, Skin irritation
Reevaluation acc. to CLP regulation, Skin irritation
Rohm & Haas 1973
Albino Rabbits
Coverage: not stated, shaved skin (results from scarified skin were regarded irrelevant)
Dosage: 3000 mg/kg, undiluted. No substance removal reported
Skin reactions
Animal Nr. |
Erythema 24 h |
Erythema 48 h |
Erythema 72h |
Mean Erythema |
Edema 24 h |
Edema 48 h |
Edema 72 h |
Mean Edema |
1 |
0 |
- |
0 |
0 |
0 |
- |
0 |
0 |
2 |
0 |
- |
0 |
0 |
0 |
- |
0 |
0 |
3 |
2 |
- |
2 |
2 |
1 |
- |
0 |
0.5 |
4 |
0 |
- |
0 |
0 |
0 |
- |
0 |
0 |
5 |
2 |
- |
2 |
2 |
1 |
- |
0 |
0.5 |
6 |
2 |
- |
2 |
2 |
1 |
- |
0 |
0.5 |
Comparison with CLP criteria:
Remark: Exposure time was longer than 4 hours (during the whole
observation time) and the observation time was only 72 hours.
All scores < 2.3. The highest mean erythema score is 2 for 3/6 animals,
the highest edema score 0.5 for 3/6 animals..
Reversibility: no pathologic changes were noted 14 days after exposure. Remarks concerning the study result: The study for acute skin irritation/ corrosion was performed before OECD 404 came into force. For this reason the test values were reevaluated according to OECD criteria and test scores (erythema, oedema) obtained for the scarified skin were regarded as irrelevant.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Not irritating: Criteria used for interp not irritating: retation of results: other: CLP, EU, GHS (Regulation (EC) No 1272/2008)
- Conclusions:
- In an acute dermal toxicity study 3000mg/kg of undiluted test substance were applicated to the shaved and shaved/abradet skin of 6 albino rabbits. Skin was observed after 24 und 72 hours for irritating reactions. Skin reactions were reevaluated acc. CLP criteria.
All scores were < 2.3. The highest mean erythema score is 2 for 3/6 animals, the highest edema score 0.5 for 3/6 animals. As the exposure time is too short, it strictly cannot be excluded that the substance has a higher irritating potential but reversibility is supposable. - Executive summary:
In an acute dermal toxicity study 3000 mg/kg of undiluted test substance were applicated to the shaved and shaved/abradet skin of 6 albino rabbits. Skin was observed after 24 und 72 hours for irritating reactions. Skin reactions were reevaluated acc. CLP criteria.
All scores were < 2.3. The highest mean erythema score is 2 for 3/6 animals, the highest edema score 0.5 for 3/6 animals. As the observation time is too short, it strictly cannot be excluded that the substance has a higher irritating potential but reversibility is supposable, but it is assumable that the animals were exposed with the test substance during the whole observation time.
According CLP classification Isodecylmethacrylate is not irritating in this study.
Remarks concerning the study result: The study for acute skin irritation/corrosion was performed before OECD 404 came into force. For this reason the test values were reevaluated according to CLP criteria and test scores (erythema, oedema) obtained for the scarified skin were regarded as irrelevant.
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