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EC number: 906-125-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Repeated Dose Toxicity:
- NOAEL: 10000 ppm > ca. 550 mg/kg bw/day (112 days)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 550 mg/kg bw/day
Additional information
Oral
No data concerning the repeated dose toxicity of the reaction mass of geraniol and nerol is available. However, the oral repeated dose toxicity was evaluated in a study (Hagan, 1967) with a mixture of 3,7-dimethyl-2,6-octadienol and 3,7-dimethyl-1,6-octadienol (named "Geraniol extra" by the authors). Due to the structural analogy, this study is used for read across, expecting the reaction mass of geraniol and nerol to have similar effects.
The test substance was feed to five male and five female individually housed Osborne-Mendel rats per dose group. Thereby, a concentration of 1000 ppm (= ca. 55 mg/kg bw/day) was administered for 189-169 days and a concentration of 10000 ppm (= ca. 550 mg/kg bw/day) was given for 112 days. During the study, the food consumption was monitored and blood was collected at the end of study and was subjected analysis of white cell counts, red cell counts and hemoglobin and hematocrit content. Also, animals were necropsied and histopathology was performed. Since no clinical signs, no effects on body weight as well as no histopathological changes were observed, the NOEL could be estimated as 10000 ppm. Thus the NOAEL would be > 550 mg/kg bw/day.
In another study, ten rats per dose were fed with 0.1% geraniol for 28 weeks and with 1% for 16 weeks (FDA, 1954). Since no effects were reported, a NOEL of 1% could be estimated. However, this data could not be considered for assessment since only concentrations of 1% and 0.1% were used and only limited data were given.
Inhalation
In an inhalative repeated-dose toxicity study, eight complex fragrance mixtures consisting of approximately 200 ingredients (close to one-half of the ingredients present at a level of 1% or more) were tested (Fukayama, 1999). Geraniol was present in 3 out of the eight mixtures and was tested in Syrian hamster and CD and Sprague-Dawley rats. They were whole-body exposed to the mixtures at 5, 9 or 50 mg/m³ for 4 h/day, 5 days/week for 6 or 13 weeks. The concentrations of fragrance in the chamber used were monitored and the found particle size ranged from 0.5 to 4.3 µm. Thereby, the highest determined exposure levels were 5.7 and 37.8 µg/m³. No gross pathological or histopathological findings related to test material exposures were observed. However, because different mixtures of substances were used in this study, the data could not be taken into account for assessment.
Justification for classification or non-classification
Based on the results from repeated dose toxicity testing no classification for specific target organ toxicity after repeated exposure is warrented according to Regulation (EC) No 1272/2008.
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