Registration Dossier
Registration Dossier
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EC number: 424-250-9 | CAS number: -
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Yellow MGi 1301
- IUPAC Name:
- Yellow MGi 1301
- Test material form:
- solid
Constituent 1
Study design
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 134 µg/L
- Duration:
- 2.4 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 102 µg/L
- Duration:
- 2.4 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 145 µg/L
Results and discussion
- Preliminary study:
- pH 4.0
The results of pH 4.0 showed a degradation of YELLOW MGi 1301 was less than 10 % at 50 °C after 5 days. According to the EEC Directive 92/69, Section C.7, it can be concluded, that the estimated half-life time is higher than one year under representative environmental conditions (25° C). Therefore, YELLOW MGi 1301 was considered to be hydrolytically stable, and no further testing was necessary.
pH 7.0 and pH 9.0
The results of pH 7.0 and pH 9.0 show that YELLOW MGi 1301 is very unstable at 50 °C. The degradation of YELLOW MGi 1301 at pH 7.0 was determined to be more 50 % after 2.4 hours of incubation. The analytical results indicate that at pH 9.0, YELLOW MGi 1301 already starts to hydrolyse immediately after being dissolved in the buffer. According to the EEC Directive 92/69, Section C.7, it can be concluded, that the estimated half-life times at pH 7.0 and pH 9.0 are shorter than one day under representative environmental conditions (25 °C). Therefore, no further testing was necessary at these pH-values. - Transformation products:
- not specified
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- > 1 yr
- Remarks on result:
- hydrolytically stable based on preliminary test
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- < 1 d
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- < 1 d
Any other information on results incl. tables
Only a preliminary study was conducted as further testing was considered unnecessary at the pH analyzed.
Applicant's summary and conclusion
- Conclusions:
- Estimated half-life time higher than one year at pH = 4
Estimated half-life times shorter than one day at pH = 7 and pH = 9
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