Registration Dossier
Registration Dossier
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EC number: 219-909-0 | CAS number: 2568-90-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 13. Aug 1968 - 02. Sep 1968
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- Method: BASF test
- GLP compliance:
- no
- Test type:
- other: Inhalation Risk Test
Test material
- Reference substance name:
- 1,1'-[methylenebis(oxy)]dibutane
- EC Number:
- 219-909-0
- EC Name:
- 1,1'-[methylenebis(oxy)]dibutane
- Cas Number:
- 2568-90-3
- Molecular formula:
- C9H20O2
- IUPAC Name:
- 1,1'-[methylenebis(oxy)]dibutane
- Details on test material:
- - Name of test material (as cited in study report): Butylal; Formaldehyddibutylacetal
- Physical state: liquid
- Analytical purity: 98-99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 173 g (mean)
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- 11. 24 mg/L (calculated from substance loss)
(calculated saturated vapor concentration: 6.6 mg/l) - No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations: several times on the day of administration, at least once each workday.
- Frequency of weighing: days 0, 7
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 11.24 mg/L air (nominal)
- Exp. duration:
- 8 h
- Remarks on result:
- other: Inhalation Risk Test: Substance concentration was calculated from substance loss during the exposure
- Mortality:
- No mortality occured.
- Clinical signs:
- other: During the exposure escape attempts, irritation of the mucous membranes and intense respiration. At the end of the exposure period high stepping almost staggering gait, tremor of the whole body. 24 h post application piloerection and calm behaviour. 48 h
- Body weight:
- The animals gained weight (no single recording of weight gain).
- Gross pathology:
- 1x bronchial pneumonia (right) and vicariious emphysema (left); 1x chronic bronchitis and bronchiectasis.
Any other information on results incl. tables
The inhalation of a highly saturated vapor-air-mixture at 20 °C caused no mortality after 8 h of exposure.
Applicant's summary and conclusion
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