Registration Dossier
Registration Dossier
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EC number: 691-865-9 | CAS number: 17696-64-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Link to relevant study records
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: other: chromosome damage, genotoxicity, mutagenicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Software used: DEREK Nexus, version 2.0.3 LHASA Ltd, Leeds, UK
- GLP compliance:
- no
- Type of assay:
- other: QSAR using Derek Nexus, version 2.0.3
- Species / strain:
- not specified
- Metabolic activation:
- not specified
- Genotoxicity:
- other: PLAUSIBLE alert for chromosome damage and mutagenicity
- Cytotoxicity / choice of top concentrations:
- not specified
- Conclusions:
- Interpretation of results (migrated information):
other: no alert for genotoxicity
other: PLAUSIBLE alert for chromosome damage and mutagenicity
No alert for genotoxicity was detected.
A plausible alert for chromosome damage and mutagenicity of the Acetic acid, 2-chloro-, 1-methylpropyl ester was detected by DEREK Nexus version 2.0.3.
Plausible - The weight of evidence supports the proposition
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No alert for genotoxicity was detected.
A plausible alert for chromosome damage and mutagenicity of the Acetic acid, 2-chloro-, 1-methylpropyl ester was detected by DEREK Nexus version 2.0.3.
Justification for selection of genetic toxicity endpoint
Only available data
Justification for classification or non-classification
Following REGULATION (EC) No 1272/2008, to arrive at a classification test results are considered from experiments determining mutagenic and/or genotoxic effects in germ and/or somatic cells of exposed animals. Mutagenic and/or genotoxic effects determined in in vitro tests shall also be considered.
The only available study is a QSAR prediction.
The test result is not judged sufficient to arrive at a classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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