Registration Dossier
Registration Dossier
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EC number: 700-880-2 | CAS number: -
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Distillate of aerobic enzymatic oxidation products of patchouli oil alpha-guaiene rich fraction
- EC Number:
- 700-880-2
- IUPAC Name:
- Distillate of aerobic enzymatic oxidation products of patchouli oil alpha-guaiene rich fraction
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- other: CBA/Ca Crl
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 5, 10 and 25%
- No. of animals per dose:
- 5
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: Vehicle Control Group: 1.00 5%: 1.25 10%: 2.82 25%: 8.25 Positive control: 6.09
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: Vehicle Control Group: 977.9 5%: 1225.7 10%: 2755.1 25%: 8063.5 Positive control: 5951.3
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- the test item Akigalawood was found a skin sensitiser and an EC3 value of 10.5% (w/v) was derived.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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