Acetamide, N,N'-(ethenylmethylsilylene)bis[N-ethyl-

Toxicity to soil macroorganisms except arthropods

Administrative data

Endpoint:

toxicity to soil macroorganisms except arthropods: short-term

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 207 (Earthworm, Acute Toxicity Tests)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide

EC Number:

643-078-7

Cas Number:

87855-59-2

Molecular formula:

C11 H22 N2 O2 Si Si(CH3)(CH=CH2)[N(CH2CH3)(C(=O)CH3)]2

IUPAC Name:

N-[ethenyl(N-ethylacetamido)methylsilyl]-N-ethylacetamide

Test material form:

solid: compact

Details on test material:

Product code: ZMAT Number 4094103
Product name: DowComing 1-6008
Chemical name: MethylVinyl Bis (N-ethylacetamido)Silane
Identity by which test item will be referred to in reports: ZMAT Number 4094103
CAS No.: 87855-59-2
Appearance: Amber liquid
Purity: 78.4% (the purity was considered when calculated the concentration)
Lot number: 091217
Storage: keep container closed at room temperature (15-25°C)

Sampling and analysis

Analytical monitoring:

no

Test substrate

Vehicle:

no

Test organisms

Test organisms (species):

Eisenia fetida

Animal group:

annelids

Study design

Study type:

laboratory study

Substrate type:

artificial soil

Limit test:

yes

Total exposure duration:

14 d

Results and discussion

Effect concentrations

Duration:

14 d

Dose descriptor:

LC50

Effect conc.:

764.4 mg/kg soil dw

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: 724.1 - 807.0 mg/kg dw

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

Based on the eeo-toxicity grading criteria in the Guidelines for Hazard
Evaluation of New Chemical Substances.. Envirorunental Protection Agency of
P.R.C. (HJ/T 154-2004), the test item is graded as a chemical with low toxicity (0)
to earthworms under the experiment condition of this study.

Executive summary:

This study was performed to assess the acute toxicity of ZMAT Nwnber

4094103 to earthworm (Eisenia foetida).

Based on the result of preliminary test, the definitive study was conducted

with concentrations of 250.0, 354.0, 500.0, 707.0 and 1000 mg/kg dry soil weight.

Concurrent control groups were performed in parallel. For test and control groups,

four replicates were used with 10 earthworms in each replicate. Artificial soil was

used in this study. After 7 days and 14 days, behavioral or pathological symptoms

were recorded and the mortality in each container was assessed.

Mortality and toxic symptoms were found in higher concentrations; visible

toxic symptoms included abrupt twist, body softer, body fluid exosmosis, lose the

ability of escaping and thinned. In the control groups, no toxic sign and death

were found.

According 10 the mortality of the test, the 14-days LCso was 764.4 mglkg dry

.oil weight and 95% confidence limit were 724.1 to 807.0 mglkg dry ,oil weight

Based on the eco-toxicity grading criteria in the Guidelines for Hazard

Evaluation of New Chemical Substances, Enviromnental Protection Agency of

P.R.C. (HJrr 154-2004), the test item is graded as a chemical with low toxicity (O)

to earthworm under the experiment condition of this study.