Registration Dossier
Registration Dossier
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EC number: 410-660-5 | CAS number: 1072830-14-8
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 200 mg/kg bw/day
- Quality of whole database:
At a dose level of 1200 mg/kg bodyweight there was a minor histopathological effect upon the stomachs of both
males and females. There was no effect on either sex during the in-life phase of the study and no effect on either reproductive
performance or offspring growth and survival. The no effect level for adult toxicity was therefore 300 mg/kg
bodyweight. The no effect level for reproductive performances was in excess of 1200 mg/kg bodyweight.
Extensive data has been determined for the key degradation products showing an absence of systemic toxic effects, rapid metabolism of organic components and lack of accumulation of titanium salts. Performing further animal studies is not justified on the basis of the existing toxicity review.
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Extensive data has been determined for the key degradation products showing an absence of systemic toxic effects, rapid metabolism of organic components and lack of accumulation of titanium salts. Performing further animal studies is not justified on the basis of the existing toxicity review.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Additional information
Extensive data has been determined for the key degradation products showing an absence of systemic toxic effects, rapid metabolism of organic components and lack of accumulation of titanium salts. Performing further animal studies is not justified on the basis of the existing toxicity review.
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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