Registration Dossier
Registration Dossier
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EC number: 932-019-3 | CAS number: -
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 1997 to June 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study at company laboratory
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN EN ISO 10712 (February 1996)
- Deviations:
- yes
- Remarks:
- The pH of the nominal 313 ug/l sample was less than 4 at the start of test
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-Keto-L-gulonic acid
- IUPAC Name:
- 2-Keto-L-gulonic acid
- Reference substance name:
- Art. 272463
- IUPAC Name:
- Art. 272463
- Details on test material:
- The study was conducted on KGA, which is the major constituent of KGA Greens.
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Pseudomonas putida
Study design
- Test type:
- static
- Water media type:
- not specified
- Limit test:
- yes
- Total exposure duration:
- 16 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 16 h
- Dose descriptor:
- EC10
- Effect conc.:
- ca. 166 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhabition of cell proliferation
- Duration:
- 16 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 220 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhabition of cell proliferation
- Duration:
- 16 h
- Dose descriptor:
- other: EC90
- Effect conc.:
- ca. 293 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: Inhabition of cell proliferation
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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