Registration Dossier
Registration Dossier
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EC number: 400-820-2 | CAS number: 84268-33-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliance, not OECD guideline
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 400-820-2
- EC Name:
- -
- Cas Number:
- 84268-33-7
- Molecular formula:
- C20H23N3O3
- IUPAC Name:
- methyl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Paste with distilled water containing 0.5% carboxymethyl- cellulose and 0.1% polysorbate 80.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Gross pathology:
- Effects on organs:
No treatment-related gross pathological effects were noted. - Other findings:
- Signs of toxicity (local):
No deaths. Dyspnoea (slight-moderate) together with
exophthalmus, ruffled fur and ventral or curved body posture
(all slight) were noted. Signs were seen from 1 hour post
dose to day 12. No treatment-related cutaneous changes were
observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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