Registration Dossier
Registration Dossier
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EC number: 413-920-6 | CAS number: 88949-33-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was performed following GLP standards and EU method B.4 guidelines. However, full study report is not available as the data is > 12 year old and summaries have been prepared using data provided by ECHA.
Data source
Reference
- Reference Type:
- other: other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 413-920-6
- EC Name:
- -
- Cas Number:
- 88949-33-1
- Molecular formula:
- C30H20N2O2
- IUPAC Name:
- 3,6-bis({[1,1'-biphenyl]-4-yl})-1H,2H,4H,5H-pyrrolo[3,4-c]pyrrole-1,4-dione
- Reference substance name:
- 3,6- bis-biphenyl-4-yl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione
- IUPAC Name:
- 3,6- bis-biphenyl-4-yl-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: NZW SPF
Test system
- Type of coverage:
- semiocclusive
- Vehicle:
- other: Moisten solid
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hours
- Number of animals:
- Three (3)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- (mean score 1)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- (mean score 2)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- (mean score 3)
- Time point:
- other: overall at 24, 48 and 72 h
- Score:
- 0
- Irritation parameter:
- edema score
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: 0 d; Max. value at end of observation period: 0 (related to all animals)
- Other effects:
- No abnormalities were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- In a study carried out in accordance with GLP and EEC guideline B.4, test substance (EC No. 413-920-6) was evaluated for its skin irritation potential by applying 500 mg under semi-occlusive coverage on skin surface of NZW SPF rabbit. Test substance was not found to be skin irritant at the applied concentration.
The test substance was not classified as skin irritant/corrosive under the test conditions.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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