Registration Dossier
Registration Dossier
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EC number: 233-135-0 | CAS number: 10043-01-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2d: Meets national standards with acceptable restrictions: short documentation, sufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Silicic acid, aluminum sodium salt
- EC Number:
- 215-684-8
- EC Name:
- Silicic acid, aluminum sodium salt
- Cas Number:
- 1344-00-9
- Details on test material:
- - Name of test material-other-Silicic acid, aluminum sodium salt
ZEOLEX 23A and ZEOLEX 7
-Name of test material : Silicic acid, aluminum sodium salt
- CAS mumber: 1344-00-9
- EC number: 215-684-8
- Generic empiricalformula: : nSiO2 • mAl203• xNa20
- Molecular weight : 60.08g/mol (SiO2)
- Substance type:inorganic
- Physical state: solid
-Colour : White
-Odour : Odourless
- Density: 2.1 g/cm3 at 20 °C
- Melting point: 1700 °C
- Boiling point: 1 >>1700 °C: not relevant for normal and intended use
- Solubility in water: 68-79 mg/l at 20 °C
- Tradenames: Sipernat, Alusil ET, Zeolex, Hydrex, Huberfil, Durabrite, Zeocopy, Tixolex, Rhodoxane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Doses:
- 5000 mg/kg (aqueous slurry 10 ml/kg, 50 % w/v)
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
Results and discussion
- Preliminary study:
- Practically Non-toxic
No mortality during 14-d posttreatment observation period.
No pathological findings on autopsy (Huber 1973
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Practically Non-toxic
- Mortality:
- No mortality during 14-d posttreatment observation period.
- Clinical signs:
- other: no
- Gross pathology:
- No pathological findings on autopsy (Huber 1973
Any other information on results incl. tables
RS-Freetext:
No mortality during 14-d posttreatment observation period.
No pathological findings on autopsy (Huber 1973, Tab. 1).
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
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